On the sup(67)Ga-binding acid mucopolysaccharide in malignant tumor

The present study was performed to determine the structure of sup(67)Ga-binding acid mucopolysaccharide in tumor tissues. It was determined from measuring neutral saccharide in the structure that the principal sup(67)Ga-binding acid mucopolysaccharide in the tumor was keratan sulfate and/or keratan polysulfate. On the other hand, it was clarified from the results of mucopolysaccharase treatment that the main sup(67)Ga-binding acid mucopolysaccharide in tumor was not keratan sulfate, heparan sulfate, heparin, nor chondroitin sulfate A, B, or C. Based on the present results, it was deduced that the main sup(67)Ga-binding acid mucopolysaccharide in tumor is keratan polysulfate, and that this acid mucopolysaccharide plays the most important role in tumor accumulation of sup(67)Ga. (author)