The influence on the expression of TGF-β1 and the contents of collagen type I and type III by high energy electrons radiation injury
- 1. Suzhou Univ., Suzhou (China). Dept. of Biochemistry and Molecular Biology
Description
To investigate the change of collagen type I and type III and the action of TGF-β1 after high energy electrons radiation. The animal model of radiation injury was established by high energy electrons radiation produced by the linear accelerator; and irradiated NIH 3T3 cells were studied. In the experiment the contents of total collagen, collagen type I and III were measured. The contents of TGF-β1 were also detected. The results showed after radiation, little change was found in the content of total collagen, but the content of collagen I decreased and the content of collagen III increased; the expression of TGF-β1 increased. Changes in the collagen metabolism were caused by the irradiated injury of the skin; TGF-β1 may be essential in the regulation of the collagen metabolism
Additional details
Publishing Information
- Journal Title
- Journal of Radiation Research and Radiation Processing
- Journal Volume
- 20
- Journal Issue
- 1
- Journal Page Range
- p. 67-71
- ISSN
- 1000-3436
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 34022683
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- BIOLOGICAL MODELS; COLLAGEN; DOSE-RESPONSE RELATIONSHIPS; ELECTRON BEAMS; EXPERIMENTAL DATA; IRRADIATION; PATHOLOGICAL CHANGES; RADIATION DOSES; RADIATION INJURIES; RADIOTHERAPY; RATS; SKIN
- Descriptors DEC
- ANIMALS; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DATA; DISEASES; DOSES; INFORMATION; INJURIES; LEPTON BEAMS; MAMMALS; MEDICINE; NUCLEAR MEDICINE; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANS; PARTICLE BEAMS; PROTEINS; RADIATION EFFECTS; RADIOLOGY; RODENTS; SCLEROPROTEINS; THERAPY; VERTEBRATES