Published September 1, 2017 | Version v1
Journal article Metadata-only

Mesoporous silica nanoparticles as potential carriers for enhanced drug solubility of paclitaxel

Creators

  • 1. School of Material Science and Engineering, Central South University, Changsha, Hunan 410083 (China)
  • 2. Institute of Super-microstructure and Ultrafast Process in Advanced Materials, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China)
  • 3. Lab of Nano-biology Technology, School of Physics and Electronics, Central South University, Changsha, Hunan 410083 (China)

Description

In this study, paclitaxel (PTX), a typical chemotherapeutic agent with poor water-solubility, was selected as the model drug to evaluate the feasibility of mesoporous silica nanoparticles (MSN) to load a hydrophobic drug in different solvents. A sol-gel method was used to synthesize MSN. Drug loading was carried out in three different solvents: dichloromethane, ethanol and dimethyl sulfoxide (DMSO) via a solvent evaporation method, and their effects on drug loading were examined. We further studied the effects of drug loading period and mass ratio of drug to carrier on drug loading capacity of MSN, as well as the in vitro drug release was analyzed. Moreover, the cytotoxic effect of PTX loaded MSN on liver carcinoma (HepG2) cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The related materials were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), dynamic light scattering (DLS), fourier transform infrared spectrometer (FTIR), small-angle x-ray scattering (SAXS), wide-angle x-ray diffraction (XRD) and N2 adsorption-desorption analyses. The results demonstrated a highly improved solubility of PTX by using MSN as drug carriers compared to free PTX. In addition, drug loading content increased as the solvent polarity parameter decreased or the drug/carrier mass ratio increased. Compared with the blank MSN, the PTX loaded MSN could produce a significant cytotoxicity on HepG2 cells. Our results indicated that MSN could be very potential drug delivery carriers for poorly water soluble drugs. - Highlights: • MSN were designed as carriers for water-insoluble PTX. • The solubility of PTX was highly improved after loading into MSN. • Drug loading capacity increased as the polar parameter of solvent decreased. • Drug loading content increased as the drug/carrier mass ratio increased. • The cytotoxicity of PTX loaded MSN increased as PTX concentration increased.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.msec.2017.04.049

Additional details

Identifiers

DOI
10.1016/j.msec.2017.04.049;
PII
S0928-4931(16)32188-9;

Publishing Information

Journal Title
Materials Science and Engineering. C, Biomimetic Materials, Sensors and Systems
Journal Volume
78
Journal Page Range
p. 12-17
ISSN
0928-4931

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
49080836
Subject category
S36: MATERIALS SCIENCE;
Descriptors DEI
DRUGS; FOURIER TRANSFORM SPECTROMETERS; INFRARED SPECTRA; NANOPARTICLES; NANOSTRUCTURES; SCANNING ELECTRON MICROSCOPY; SILICA; SMALL ANGLE SCATTERING; SOL-GEL PROCESS; SOLUBILITY; SOLVENTS; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY; X-RAY DIFFRACTION
Descriptors DEC
COHERENT SCATTERING; DIFFRACTION; ELECTRON MICROSCOPY; MEASURING INSTRUMENTS; MICROSCOPY; MINERALS; OXIDE MINERALS; PARTICLES; SCATTERING; SPECTRA; SPECTROMETERS

Optional Information

Copyright
Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.