Published May 1998
| Version v1
Journal article
animal experiments of radioiodinated ω-p-iodophenyl pentadecanoic acid
- 1. State Key Laboratory of Nuclear Medicine Jiangsu Inst. of Nuclear Medicine, Wuxi (China)
Description
The purpose of the author was to investigate in vivo behavior of biodistribution and elimination of myocardial viability imaging agent 125I-IPPA. Myocardial uptake of 125I-IPPA in rats showed a peak of 4.4% of injected dose per gram at 1 min. The half elimination time of myocardium was 3.8 min. The maximal uptake of thyroid was only 0.005%ID/organ at 120 min. The initial half time of 2.7 min in rabbits was obtained from the elimination curve of radioactivity in blood. In vitro binding test for 125I-IPPA to HSA showed rather constant level of activation during the two hours. The second peak of extraction was observed in major organs of rat, in rabbits' elimination of radioactivity, in vivo binding test for 125I-IPPA to HSA
Additional details
Publishing Information
- Journal Title
- Nuclear Techniques
- Journal Volume
- 21
- Journal Issue
- 5
- Journal Page Range
- p. 289-292
- ISSN
- 0253-3219
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 29044201
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- BENZENE; BLOOD; CARBOXYLIC ACIDS; EXCRETION; IODINE 125; KIDNEYS; LABELLING; METABOLISM; MICE; MYOCARDIUM; PROTEINS; RABBITS; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; UPTAKE
- Descriptors DEC
- ANIMALS; AROMATICS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; CLEARANCE; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEART; HYDROCARBONS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; VERTEBRATES