Studies on technetium-99m-labelled monophosphates: 1,2-epoxypropylphosphonic acid and its hydrolysed form

1,2-Epoxypropylphosphonic acid (fosfomycin) when labelled with 99mTc at pH - 6.8 was described as a renal imaging agent. Under the same experimental conditions, except pH=2.5, 99mTc fosfomycin has shown bone uptake. The hydrolysed form of fosfomycin, the 1,2-dihydroxypropyl-1-phosphonic acid when labelled with 99mTc in identical conditions, also has shown similar biological behaviour. Extraction and adsorption experiments conducted on both radiopharmaceuticals have shown that renal uptake preparations are Tc(V) complexes, meanwhile bond uptake preparations are Tc(IV) and/or Tc(III) complexes. (Author)