Published November 1996 | Version v1
Journal article Metadata-only

Synthesis of 3H and 14C labelled Sch 48461

Creators

  • 1. Schering Plough Research Inst., Kenilworth, NJ (United States)

Description

3H-Sch 47949, racemic 3H-Sch 48461, was prepared at a specific activity of 40 mCi/mmole by Pt catalysed exchange with tritiated water. 3H-Sch 48461 was prepared at a specific activity of 64.6 Ci/mmole by a Pd/C catalysed reduction of an olefinic intermediate. 14C-Sch 48461 was prepared in 8 steps from 14C-potassium cyanide with an overall radiochemical yield of 18.5%. (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
38
Journal Issue
11
Journal Page Range
p. 1039-1046.
ISSN
0362-4803
CODEN
JLCRD4

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
28048439
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CARBON 14; CHEMICAL PREPARATION; CHOLESTEROL; CYANIDES; DIET; LABELLING; POTASSIUM COMPOUNDS; RADIOPHARMACEUTICALS; TRITIUM
Descriptors DEC
ALKALI METAL COMPOUNDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBON ISOTOPES; DRUGS; EVEN-EVEN NUCLEI; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; STEROIDS; STEROLS; SYNTHESIS; YEARS LIVING RADIOISOTOPES