Changes in blood and hemopoiesis of rats exposed to exponentially decreasing dose rates of continuous gamma irradiation. 3

Changes were followed of some serum proteins in rats exposed continuously for 10 days with the use of exponentially decreasing dose rates simulating approximately a drop of the radioactivity in an environment contaminated by a fission mixture of radionuclides. A maximal reduction of concentrations of prealbumin, albumin, A1-globulin and transferrin was induced in the course of irradiation by an accumulated dose of 11.484 Gy (97th hour of irradiation). In an interval of cumulated doses of 11.484 to 14.355 Gy, there was a certain recovery to normal values between the 4th and 10th days. In the course of irradiation an increased concentration was found only in haptoglobin for a cumulated dose of 7.656 Gy. In most proteins of interest, there was, already after the 7th to 14th days from completing irradiation, an increase to normal values and in prealbumin, haptoglobin and C3 component of the complement, the values from the 14th or 28th to 90th days were increased. (author)