Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms
Creators
- 1. Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine (Japan)
- 2. Department of Neurosurgery, Kyoto University Graduate School of Medicine (Japan)
- 3. Department of Neurosurgery, National Cerebral and Cardiovascular Center (Japan)
- 4. International Mass Imaging Center and Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine (Japan)
- 5. Riken Center for Molecular Imaging Science (Japan)
- 6. Division of Neural Systematics, National Institute for Physiological Sciences (Japan)
- 7. Department of Anatomy, The University of Hong Kong (Japan)
- 8. Preeminent Medical Photonics Education & Research Center (Japan)
Description
Highlights: • Heterogeneity of IA walls was examined with imaging mass spectroscopy. • Phosphatidylinositol (PI 18:0/20:4) was more abundant in the thickened wall of IAs. • SMCs in thick and thin wall were dedifferentiated and differentiated, respectively. • Dedifferentiated SMCs had higher levels of PI (18:0/20:4) than differentiated SMCs. • PI (18:0/20:4) could be associated with phenotypic switching of SMCs in rat IAs. The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular diseases. To investigate the feature of phospholipid composition of IA walls, we conducted IMS in a rat model of experimentally induced IA.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.bbrc.2017.10.133Additional details
Identifiers
- DOI
- 10.1016/j.bbrc.2017.10.133;
- PII
- S0006291X17321186;
Publishing Information
- Journal Title
- Biochemical and Biophysical Research Communications
- Journal Volume
- 495
- Journal Issue
- 1
- Journal Page Range
- p. 332-338
- ISSN
- 0006-291X
- CODEN
- BBRCA9
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 53017129
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- PHOSPHOLIPIDS; RATS; VASCULAR DISEASES
- Descriptors DEC
- ANIMALS; CARDIOVASCULAR DISEASES; DISEASES; ESTERS; LIPIDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; RODENTS; VERTEBRATES
Optional Information
- Copyright
- Copyright (c) 2017 Elsevier Inc. All rights reserved.