Optimization of the direct utilization of irradiated *TeO2 for meta-iodo-benzyl guanidine (M-IBG) radioiodination via gas-solid isotopic exchange

The technical parameters and thermodynamic characteristics of the direct radioiodination of meta-iodo benzyl-guanidine 0.5 sulphate (M-IBG. 0.5 H2SO4) by technique basically depends on a heterogeneous isotopic exchange reaction between M-IBG. 0.5 H2SO4 molecule and radioiodine gas produced by heating *TeO2 up to 550 c degree - c degree via dry Al2O3 column previously deactivated by 0.1 N H2SO4 (ph approx= 1.2) in a relation of 3 mg/97 mg Al2O3. A radiochemical yield over 95% has been obtained with 20-30 min by performing the isotopic exchange at 140-160 c degree. The technique allows the possible utilization of *TeO2 irradiated from either nuclear reactors or cyclotrons using neutron gamma or protons (i.e. 134TeO2) and deuterons (i.e. 132TeO2) respectively. Different radio chromatographic analysis has already been used to determine the radiochemical yields % and the radionuclidic purity as well as the radiochemical purity