Chapter 11: Development of technetium-99m labelled biomarkers for heart metabolism using the Tc-tricarbonyl core

Synthesis and evaluation of a new fatty acid derivative labelled with 99mTc was undertaken. Four derivatives of undecanoic acid and two derivatives of hexadecanoic acid were synthesized and their coordination chemistry with 99mTc- and Re-tricarbonyl cores was investigated. The Re(I) complex was prepared with a good yield by refluxing the ligand with [NEt4]2[ReBr3(CO)3] in methanol and was characterized by spectroscopic methods. Four of the derivatives were provided to groups in China, India and the Russian Federation, and in these laboratories high performance liquid chromatography (HPLC) analysis demonstrated that the reaction produces a single complex with a high yield. The 99mTc complexes were characterized by comparative HPLC studies using a sample of a well characterized Re(I) complex as reference. (author)