Published April 2015 | Version v1
Book Metadata-only

A New Class of 99mTc(I) Agents for SLND: Labelling and Quality Control. Chapter 6

Creators

  • 1. Unidade de Ciências Químicas e Radiofarmacêuticas, ITN, Instituto Superior Técnico, Universidade Técnica de Lisboa, Sacavém (Portugal)
  • 2. Institute of Biosciences & Applications, Demokritos National Center for Scientific Research, Athens (Greece)
  • 3. Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, Demokritos National Center for Scientific Research, Athens (Greece)

Description

In an attempt to prepare a new class of tracers for SLND, the radiolabelling of mannosylated dextran derivatives containing the tridentate pz diamine and cysteine chelators for stabilization of the organometallic core fac-[99mTc(CO)3]+ are reported. This chapter demonstrates the optimization of the labelling conditions to achieve high radiochemical purity and specific activity. These results are of paramount importance for the biological properties of the compounds, namely their mannose receptor targeting properties. (author)

Part of:
Radiopharmaceuticals for Sentinel Lymph Node Detection: Status and Trends

Additional details

Identifiers

URL
http://www-pub.iaea.org/MTCD/Publications/PDF/Pub1674web-3264500.pdf; http://www.iaea.org/books;

Publishing Information

Publisher
IAEA
Imprint Place
Vienna (International Atomic Energy Agency (IAEA))
ISBN
978-92-0-109714-9
Imprint Title
Radiopharmaceuticals for Sentinel Lymph Node Detection: Status and Trends
Imprint Pagination
179 p.
Journal Issue
no. 6
Series
IAEA Radioisotopes and Radiopharmaceuticals Series
Journal Page Range
p. 109-115
ISSN
2077-6462

INIS

Country of Publication
International Atomic Energy Agency (IAEA)
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
46119509
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
CYSTEINE; DEXTRAN; IMPURITIES; LABELLING; MANNOSE; OPTIMIZATION; QUALITY CONTROL; RADIOPHARMACEUTICALS; STABILIZATION; TECHNETIUM 99
Descriptors DEC
ALDEHYDES; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD SUBSTITUTES; CARBOHYDRATES; CARBOXYLIC ACIDS; CONTROL; DRUGS; HEMATOLOGIC AGENTS; HEXOSES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MONOSACCHARIDES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; POLYSACCHARIDES; RADIOACTIVE MATERIALS; RADIOISOTOPES; SACCHARIDES; TECHNETIUM ISOTOPES; THIOLS; YEARS LIVING RADIOISOTOPES

Optional Information

Contract/Grant/Project number
Grant FCT SFRH/BD/48066/2008
Notes
16 refs., 1 tab., 3 figs.
Secondary number(s)
STI/PUB--1674