Two cases of locally recurrent rectal cancer after intersphincteric resection that were controlled with a combination of chemoradiotherapy and abdominoperineal resection

We report 2 cases of locally recurrent rectal cancer after lntersphincteric resection (ISR) that were controlled with a combination of chemoradiotherapy and abdominoperineal resection (APR). In Case 1, we performed preoperative chemoradiotherapy (TS-1 plus RT 45 Gy) and APR for the local recurrence of ISR. On pathology, viable neoplastic cells were noted. In Case 2, we performed preoperative chemotherapy (Bmab plus mFOLFOX6) and APR for the local recurrence of ISR. On pathology, no viable neoplastic cells were noted. However, a local recurrence developed again 3 months later. Therefore, we performed chemoradiotherapy (TS-1 plus RT 53 Gy). The 2 patients survived without recurrence until now. Their pathology tissues and clinical courses showed that control of local recurrence with only chemoradiotherapy or surgical resection was likely to be difficult. We might be able to improve the prognosis of patients with a combination of chemoradiotherapy and surgical resection. (author)