Comparison of L-thyroxine and a saturated solution of potassium iodide in preventing damage to the thyroid following iodine-131-labeled antibody injection
Creators
- 1. Veterans Administration Medical Center, Seattle, WA
Description
Following injection of radioiodinated antibodies in diagnostic amounts, there is variable uptake of radioiodine by the thyroid. Unless preventive steps are taken, radiation damage to the gland may occur. We have evaluated the role of L-thyroxine and a saturated solution of potassium iodide (SSKI) in preventing radiation damage to the thyroid glands of Sprague-Dawley adult male rats by measuring DNA strand breakage by the nucleoid sedimentation gradient method. Pretreatment with SSKI reduced DNA damage and also reduced 131I accumulation in the thyroid. Pretreatment with L-thyroxine also reduced DNA damage without significantly reducing 131I accumulation in the thyroid. The possible mechanisms of action of L-thyroxine and SSKI in preventing radiation damage to the thyroid are addressed
Additional details
Publishing Information
- Journal Title
- NCI Monogr.
- Journal Issue
- no.3
- Series
- NCI Monogr.
- CODEN
- NCIME
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18073012
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- COMPARATIVE EVALUATIONS; DNA; GENETIC RADIATION EFFECTS; IODINE 131; POTASSIUM IODIDES; RADIATION INJURIES; RADIONUCLIDE KINETICS; RATS; SIDE EFFECTS; STRAND BREAKS; THYROID; THYROXINE; UPTAKE
- Descriptors DEC
- ALKALI METAL COMPOUNDS; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; CARBOXYLIC ACIDS; DAYS LIVING RADIOISOTOPES; DISEASES; ENDOCRINE GLANDS; EVALUATION; GENETIC EFFECTS; GLANDS; HALIDES; HALOGEN COMPOUNDS; HORMONES; INJURIES; INTERMEDIATE MASS NUCLEI; IODIDES; IODINE COMPOUNDS; IODINE ISOTOPES; ISOTOPES; KINETICS; MAMMALS; NUCLEI; NUCLEIC ACIDS; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; PEPTIDE HORMONES; POTASSIUM COMPOUNDS; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; THYROID HORMONES; VERTEBRATES