Preditox: evaluation of repair test predicting the radio-induced toxicity

As 200.000 patients including 700 children are treated by irradiation every year in France, and as more than 5 per cent are exposed to non-predictable after-effects, the authors report the development of a diagnosis test for adults based on the in-vitro estimation of the functional repair and signalling of DNA double strand breaks. By using indirect immunofluorescence, they demonstrate a quantitative correlation between cellular quantitative sensitivity and the rates of non-repaired DNA double strand beaks. This approach, called Preditox, has been validated on 80 patients and presents the required characteristics to be a screening test of radio-sensitive patients. Short communication