Studies on the distribution of 125I-labelled Hemorrhagic toxin from agkistrodon acutus (125I-AaT) in rabbits and its pharmacokinetic characters

125I-AaT, prepared by oxidant-chloroamine T from the related venom of Agkistrodon Acutus, is given to a rabbit by intravenous injection, and then, the distribution of the toxin in the rabbit and its pharmacokinetic characters have been studied.The rabbit is killed five hours after the injection, and the radioactivity in each tissue calculated. The result indicates that the blood-brain barrier exist in the body, and large quantity of by-products of 125I-AaT metabolism is eliminated from urine by the kidney. For pharmacokinetics, the computer simulated curve demonstrates that the result conforms to the Two Compartment Model. The fast component half-life T1/2α is 3.15 mins. , the slow component half-life T1/2β is 165 mins. , and the biological half-life T1/2 is 75.2 mins.Vd33, Vt and Ve have been analyzed, and the author thinks preliminarily that there must have been a corresponding receptor to the toxin in the body