Published January 2002 | Version v1
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Improved synthesis of S-[18F-Fluoromethyl]-(+)-McN5652

Creators

  • 1. Turku PET Centre, Radiochemistry Lab. (Finland)

Description

A modified procedure for the synthesis of S-[18F-fluoromethyl]-(+)-McN5652 is described. Hydrolysis of the thioester precursor 1 with an aqueous potassium hydroxide solution prevents the formation of a polar side product. Under these conditions the radiochemical yield was increased to 16 ± 4% (corrected for decay and related to starting [18F]fluoride). (orig.)

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Part of:
Institute of Bioinorganic and Radiopharmaceutical Chemistry. Annual report 2001

Additional details

Publishing Information

Imprint Title
Institute of Bioinorganic and Radiopharmaceutical Chemistry. Annual report 2001
Imprint Pagination
113 p.
Journal Page Range
p. 33
ISSN
1437-322X
Report number
FZR--340

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
35062608
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHEMICAL REACTION YIELD; FLUORINE 18; HYDROLYSIS; LABELLED COMPOUNDS; PRECURSOR; SYNTHESIS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; DECOMPOSITION; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; LYSIS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; SOLVOLYSIS; YIELDS

Optional Information