Published February 2004 | Version v1
Journal article Metadata-only

Monitoring individual response to brain-tumour chemotherapy: proton MR spectroscopy in a patient with recurrent glioma after stereotactic radiotherapy

Creators

  • 1. Department of Radiology, German Cancer Research Centre, Im Neuenheimer Feld 280, 69120, Heidelberg (Germany)
  • 2. Department of Nuclear Medicine, University of Heidelberg, 69120, Heidelberg (Germany)
  • 3. Department of Neurology, University of Heidelberg, 69120, Heidelberg (Germany)
  • 4. Radiological Clinic, University of Heidelberg, 69120, Heidelberg (Germany)
  • 5. Radiological Clinic, University of Tuebingen, 72076, Tuebingen (Germany)

Description

Since antineoplastic activity varies, sensitive methods for individual assessment of efficacy are needed. We demonstrate the clinical value of MR spectroscopy in monitoring chemotherapy in a patient with recurrent glioma after stereotactic radiotherapy. Diagnostic imaging before and after chemotherapy included contrast-enhanced MRI, single-voxel proton MR spectroscopy (1H MRS), 1H MR spectroscopic imaging (1H SI), and fluorodeoxyglucose (FDG) positron-emission tomography (PET). A significant decrease in choline signal intensity was observed 2 months after chemotherapy indicating tumour chemosensitivity, in line with tumour shrinkage on MRI and decreased uptake of FDG. Assessment of early response by MRS may help to improve treatment protocols in other patients. (orig.)

Availability note (English)

Available from: http://dx.doi.org/10.1007/s00234-003-1116-8

Additional details

Identifiers

DOI
10.1007/s00234-003-1116-8;

Publishing Information

Journal Title
Neuroradiology
Journal Volume
46
Journal Issue
2
Journal Page Range
p. 126-129
ISSN
0028-3940
CODEN
NRDYAB

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
35026670
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BRAIN; CHEMOTHERAPY; CHOLINE; FLUORODEOXYGLUCOSE; MONITORING; NMR IMAGING; PATIENTS; PROTONS; RADIOTHERAPY; SIGNALS; SPECTROSCOPY; UPTAKE
Descriptors DEC
ALCOHOLS; AMINES; AMMONIUM COMPOUNDS; ANTIMETABOLITES; BARYONS; BODY; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DRUGS; ELEMENTARY PARTICLES; FERMIONS; HADRONS; HYDROXY COMPOUNDS; LIPOTROPIC FACTORS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; NUCLEONS; ORGANIC COMPOUNDS; ORGANS; QUATERNARY COMPOUNDS; RADIOLOGY; THERAPY