Published May 2013
| Version v1
Journal article
A feedback control perspective on models of apoptosis signal transduction
- 1. School of Mathematics, The University of Manchester, Manchester, England (United Kingdom)
- 2. Department of Electrical Engineering and Computer Science (Institut Montefiore) and GIGA (Interdisciplinary Cluster for Applied Geno-proteomics), Université de Liège (Belgium)
- 3. Division of Developmental Biology, Biomedical Research Foundation of the Academy of Athens, Athens (Greece)
- 4. Hamilton Institute, National University of Ireland Maynooth, Maynooth (Ireland)
Description
Apoptosis is a key regulator for replacing unused, old and damaged cells. Here we analyse three models of apoptosis. We deconstruct these models by linearising the models about the life steady state and applying methods from linear control theory. This control viewpoint uncovers a decentralised control scheme with a clear separation of plant and controller and reveals that the caspase inhibitors act as decentralised phase lead controllers
Availability note (English)
Available from http://dx.doi.org/10.1016/j.chaos.2013.01.009Additional details
Identifiers
- DOI
- 10.1016/j.chaos.2013.01.009;
- PII
- S0960-0779(13)00013-1;
Publishing Information
- Journal Title
- Chaos, Solitons and Fractals
- Journal Volume
- 50
- Journal Page Range
- p. 93-99
- ISSN
- 0960-0779
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 45052719
- Subject category
- S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS;
- Descriptors DEI
- APOPTOSIS; CONTROL THEORY; DAMAGE; FEEDBACK; SIGNALS; STEADY-STATE CONDITIONS
Optional Information
- Copyright
- Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.