Published March 2, 1979 | Version v1
Journal article

Chlorine kinetic isotope effects in the methylation of pyridine and 2,6-lutidine

  • 1. State Univ. of New York, Stony Brook

Description

Pyridine and 2,6-lutidine were methylated with methyl chloride in bromobenzene solution in sealed glass ampoules at 100.00C. The ionic chloride was isolated, purified, and completely reconverted to methyl chloride. Isotope ratios were determined with an isotope ratio mass spectrometer. It appears that the increase in the transition state is a manifestation of the Hammond postulate--the most hindered and slowest reaction possessing the most product-like transition state. 1 table

Additional details

Publishing Information

Journal Title
J. Org. Chem.
Journal Volume
44
Journal Issue
5
Series
J. Org. Chem.
Journal Page Range
889-891
ISSN
0022-3263