Resveratrol as a plant type antioxidant modifier for polysulfone membranes to improve hemodialysis-induced oxidative stress

Highlights: • Resveratrol, a natural plant-based antioxidant, was introduced into polysulfone dialysis membrane. • The modified membranes had strong oxidation resistance that could scavenge free radicals and inhibit lipid peroxidation. • The antioxidant activity of modified membranes was extraordinary stable for 60 d preservation. • The modified membranes had excellent blood compatibility, cytocompatibility and dialysis performance. Resveratrol (RES) is a plant extract with excellent antioxidant, biocompatibility, anti-inflammatory and inhibition of platelet aggregation. RES-modified polysulfone (PSF) hemodialysis membranes have been fabricated using an immersion phase transformation method. The antioxidant properties of the blend membranes were evaluated in terms of their 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS⁺), reactive oxygen species (ROS) free radicals scavenging, total antioxidant capacity (T-AOC) of serum and lipid peroxidation inhibition. The observed results of decreasing DPPH and ABTS⁺ levels, scavenging ROS, significant inhibition of lipid peroxidation and improving the T-AOC of serum all contribute to the recovery of oxidative balance and the use of RES as an antioxidant modifier. The antioxidant stability of PSF/RES blend membranes was also studied. Moreover, the results of blood compatibility experiments showed that the addition of RES improved the blood compatibility of PSF membrane, inhibited the adhesion of red blood cells and platelets; inhibited complement activation; and reduced the blood cells deformation rate. The dialysis simulation experiment indicated that PSF/RES membrane (M-3) can clear 90.33% urea, 89.50% creatinine, 74.60% lysozyme and retention 90.47% BSA. All these results showed the new PSF/RES blend membranes have potential to be used in the field of hemodialysis to improve oxidative stress status in patients.