Published 1978
| Version v1
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Influence of X-irradiation on the regeneration of the rat liver after the partial hepatectomy
- 1. Univerzita P.J. Safarika, Kosice (Czechoslovakia). Inst. of General Biology
Description
Some biochemical and morphological changes in the regenerating rat liver after whole-body exposure to 600 R of X-irradiation were studied. The irradiation caused the profound inhibition of the DNA synthesis / about 80% at 24 h hour after partial hepatectomy / and the retardation in the nucleic acid increment. The mitotic activity during the regeneration period was reduced to about 60%. The relative number of the binuclear hepatocytes was significantly lower compared with the non-irradiated animals. The enlargement of the liver weight and cellularity was also retarded. (orig.)
Availability note (English)
MF available from INIS under the Report Number.Abstract (German)
Es wurden einige biochemische und morphologische Veraenderungen in der regenerierenden Rattenleber nach Ganzkoerperbestrahlung mit Roentgenstrahlen (600 R) untersucht. Die Bestrahlung bewirkte eine weitgehende Hemmung der DNS'Synthese (ca. 80% 24 h nach partieller Hepatektomie)und eine Verzoegerung der Nukleinsaeurevermehrung. Die mitotische Aktivitaet war waehrend der Regenerationsperiode auf ca. 60% herabgesetzt, auch lag die Anzahl der binuklearen Hepatozyten wesentlich niedriger als bei den unbestrahlten kontrollierten. Gewichtszunahme der Leber und Zellaufbau waren ebenfalls verzoegert. (orig.)
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Additional details
Publishing Information
- Imprint Pagination
- 10 p.
- Report number
- INKA-Conf--78-077-047
Conference
- Title
- 14. annual meeting of the European Society of Radiation Biology.
- Dates
- 9 - 13 Oct 1978.
- Place
- Juelich, Germany, F.R.
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 10469654
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REGENERATION; BIOSYNTHESIS; COMPARATIVE EVALUATIONS; DNA; HEPATECTOMY; INHIBITION; LINERS; MITOSIS; RADIATION DOSES; RATS; WHOLE-BODY IRRADIATION; X RADIATION
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; CELL DIVISION; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MEDICINE; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; SURGERY; SYNTHESIS; VERTEBRATES