Published February 1987
| Version v1
Journal article
Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro
Description
In a pre-B-cell line that rearranges its heavy chain gene segments in vitro, the authors found that the rate of productive rearrangement on one allele was not influenced by the presence of heavy chain protein encoded by the other allele. This shows that allelic exclusion of heavy chain genes is not regulated at the genetic level. Cells were labelled with [35S]methionine. RNA was probed with a [32P]cDNA probe
Additional details
Publishing Information
- Journal Title
- Proc. Natl. Acad. Sci. U.S.A
- Journal Volume
- 84
- Journal Issue
- 4
- Series
- Proc. Natl. Acad. Sci. U.S.A.
- Journal Page Range
- 1060-1064
- ISSN
- 0027-8424
- CODEN
- PNASA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 19022228
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- BIOSYNTHESIS; DNA SEQUENCING; ELECTROPHORESIS; GENES; GENETIC MAPPING; IMMUNOGLOBULINS; LYMPHOCYTES; METHIONINE; PHOSPHORUS 32; SULFUR 35
- Descriptors DEC
- AMINO ACIDS; ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DRUGS; EVEN-ODD NUCLEI; GLOBULINS; ISOTOPES; LEUKOCYTES; LIGHT NUCLEI; LIPOTROPIC FACTORS; MATERIALS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PHOSPHORUS ISOTOPES; PROTEINS; RADIOISOTOPES; SOMATIC CELLS; STRUCTURAL CHEMICAL ANALYSIS; SULFUR ISOTOPES; SYNTHESIS