Published 1979 | Version v1
Journal article Metadata-only

Biological effects of negative pions in monolayers and spheroids of Chinese hamster cells

Creators

  • 1. Kernforschungszentrum Karlsruhe G.m.b.H. (Germany, F.R.). Inst. fuer Genetik und Toxikologie von Spaltstoffen

Description

The therapeutic value of pion irradiation was critically challenged by examining, in a cell culture system, various parameters of biological significance such as relative biological efficiency (RBE), oxygen enhancement ratio (OER), DNA-break formation, changes in cell cycle kinetics and regrowth. In all parameters, pions were superior to conventional low-LET radiation. (orig.)

Abstract (German)

Durch die Untersuchung verschiedener biologisch signifikanter Parameter in Zellkultursystemen wurde der therapeutische Wert der Pionenbestrahlung kritisch herausgefordert. Die Parameter waren: relative biologische Wirksamkeit RBW, Sauerstoffsensibilisierungsfaktor (OSF), DNS-Bruchbildung, Veraenderung in der Kinetik von Zellzyklen und Wiederwuchs. In allen Parametern waren die Pionen der konventionellen Niedrig-LET-Bestrahlung ueberlegen. (orig.)

Additional details

Publishing Information

Journal Title
Radiat. Environ. Biophys.
Journal Volume
16
Journal Issue
3
Series
Radiat. Environ. Biophys.
Journal Page Range
273-277

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
11499565
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Numerical Data
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; CELL CYCLE; DNA; EXPERIMENTAL DATA; FIBROBLASTS; INACTIVATION; IRRADIATION; ISODOSE CURVES; ISOLATED VALUES; KINETICS; LET; OXYGEN ENHANCEMENT RATIO; PION BEAMS; PIONS MINUS; RBE; STRAND BREAKS
Descriptors DEC
ANIMAL CELLS; ANTIMATTER; ANTIMESONS; ANTIPARTICLES; BEAMS; BIOLOGICAL EFFECTS; BOSONS; CONNECTIVE TISSUE CELLS; DATA; DATA FORMS; ELEMENTARY PARTICLES; ENERGY TRANSFER; HADRONS; INFORMATION; MATTER; MESON BEAMS; MESONS; NUCLEIC ACIDS; NUMERICAL DATA; ORGANIC COMPOUNDS; PARTICLE BEAMS; PIONS; PSEUDOSCALAR ANTIMESONS; PSEUDOSCALAR MESONS; RADIATION EFFECTS; SOMATIC CELLS