Published February 1986 | Version v1
Journal article Metadata-only

Mechanism of the antistress action of d-ala2-leu5-arg6-enkephalin

Creators

  • 1. Laboratory of Radionuclide Methods of Investigation, Siberian Branch, All-Union Cardiologic Scientific Center, Academy of Medical Sciences of The USSR, Tomsk

Description

The authors study the effect of the arginine-containing hexapeptide analog of Leu-enkephalin - D-Ala2-Leu5-Ar6--enkephalin (enkephalin) on blood plasma levels of ACTH, cortisol, and hormones of the pituitary-thyroid complex, and the cAMP concentration in adrenal and thymus tissues during stress induced by crushing the soft tissues (CST). The experiments were carried out on noninbred male albino rats. The plasma ACTH and cortisol levels were determined by radioimmunoassay using kits from France, thyroxine (T4) and tri-iodothyronine (T3), and pituitary thyrotropic hormone. A gamma-spectrometer and beta-scintillation counter were used

Additional details

Publishing Information

Journal Title
Bull. Exp. Biol. Med. (Engl. Transl.)
Journal Volume
100
Journal Issue
9
Series
Bull. Exp. Biol. Med. (Engl. Transl.).
Journal Page Range
1159-1161
ISSN
0007-4888
CODEN
BEXBA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
18035959
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ACTH; ADRENAL GLANDS; AMP; BIOLOGICAL EFFECTS; BIOLOGICAL STRESS; BLOOD PLASMA; CRUSHING; ENKEPHALINS; HYDROCORTISONE; RADIOIMMUNOASSAY; RATS; SCINTILLATION COUNTING; THYMUS; THYROXINE; TISSUES; TRIIODOTHYRONINE
Descriptors DEC
ADRENAL HORMONES; AMINO ACIDS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENT; BIOLOGICAL MATERIALS; BLOOD; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; CORTICOSTEROIDS; COUNTING TECHNIQUES; DRUGS; ENDOCRINE GLANDS; ENDORPHINS; GLANDS; GLUCOCORTICOIDS; HORMONES; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; KETONES; LYMPHATIC SYSTEM; MAMMALS; MATERIALS; MECHANICAL FRAGMENTATION; NEUROREGULATORS; NUCLEOTIDES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; PITUITARY HORMONES; POLYPEPTIDES; PREGNANES; PROTEINS; RODENTS; STEROID HORMONES; STEROIDS; THYROID HORMONES; TRACER TECHNIQUES; VERTEBRATES

Optional Information

Notes
Cover-to-cover translation of Byulleten' Ehksperimental'noj Biologii i Meditsiny (USSR).