Published October 2012 | Version v1
Journal article Metadata-only

The added value of 99Tcm-MDP SPECT/CT combined with three-phase bone scintigraphy for differential diagnosis in patients with suspected bone tumor

Creators

  • 1. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Nuclear Medicine Institute of Fudan University, Shanghai Institute of Medical Imaging (China)

Description

Objective: To investigate the added value of SPECT/CT combined with three-phase bone scintigraphy for differential diagnosis in patients with suspected bone tumor compared with 99Tcm-MDP three-phase bone scintigraphy. Methods: Forty-five patients with mean age (44.1 ±21.2) years who were suspected to have bone tumors, underwent 99Tcm-MDP three-phase bone scintigraphy and SPECT/CT between July 2008 and September 2011. They were retrospectively reviewed. All patients had pathological diagnosis based on surgical resection or lesion biopsy.The three-phase bone scintigraphy images were analyzed, and combined SPECT/CT images were then analyzed by two experienced nuclear medicine physicians. The third nuclear medicine physician would be consulted if there was disagreement between these two investigators.Each lesion was diagnosed as either malignant or benign. Compared with the pathology diagnosis,the diagnostic ability of three-phase bone scintigraphy images and SPECT/CT combined with three-phase bone scintigraphy were evaluated. The diagnostic accuracy of three-phase bone scintigraphy images and SPECT/CT combined with three-phase bone scintigraphy were calculated, and χ2 test was used to compare the difference between them. Results: Among these 45 lesions, 29 were malignant and 16 benign. Using three-phase bone scintigraphy and SPECT/CT combined with three-phase bone scintigraphy for the differential diagnosis of bone lesions, the sensitivity,specificity, positive predictive value and negative predictive value were 96.6% (28/29) vs 100% (29/29), 37.5% (6/16) vs 81.2% (13/16), 73.7% (28/38) vs 90.6% (29/32), and 6/7 vs 100% (13/13), respectively. The diagnostic accuracy of the three-phase bone scintigraphy was 75.6% (34/45), and up to 93.3% (42/45) for the combined examination (χ2=4.145, P<0.05). Conclusions: Compared with three-phase bone scintigraphy alone, the diagnostic accuracy of SPECT/CT combined with three-phase bone scintigraphy is significantly improved. The combination might provide added value over three-phase bone scintigraphy for differential diagnosis in patients with suspected bone tumor. (authors)

Additional details

Publishing Information

Journal Title
Chinese Journal of Nuclear Medicine and Molecular Imaging
Journal Volume
32
Journal Issue
5
Journal Page Range
p. 363-367
ISSN
2095-2848

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
46111527
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACCURACY; CARCINOMAS; CAT SCANNING; COMPARATIVE EVALUATIONS; DIAGNOSIS; IMAGES; NEOPLASMS; PATHOLOGICAL CHANGES; PATHOLOGY; PATIENTS; PHOSPHONATES; RADIOPHARMACEUTICALS; SENSITIVITY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SKELETAL DISEASES; SKELETON; SPECIFICITY; SURGERY; TECHNETIUM 99
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVALUATION; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MEDICINE; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; TECHNETIUM ISOTOPES; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
3 figs., 14 refs.