Stochastic lung dose modelling

Large inter- as well as intra-subject variabilities have been observed in all morphological and physiological parameters involved in lung dosimetry. Anatomical data on human lungs were analyzed to define probability distributions of airway diameters, lengths and branching angles. Experiments with radioactive-labelled aerosols were conducted to study particle deposition in bifurcation tubes. Preliminary stochastic dose calculations for inhaled radon decay products yielded highly skewed basal cell dose distributions which can be approximated in most cases by lognormal distributions. (Author)