Published 1989 | Version v1
Report Metadata-only

Specific property of aminothiol-derived radioprotectants in oxygen transmembrane transport inhibition

Creators

  • 1. Centre de Recherches du Service de Sante ds Armees, 38 - La Tronche (France)

Description

Preliminary reports had demonstrated, by saturation technique in ESR, the capability of cysteamine to inhibit oxygen transport in phospholipidic model membranes. This methodology was applied to different classes of radioprotective agents (aminothiol derivatives, nitriles) or cysteamine catabolites and revealed the specificity of aminothiol derivatives in such a mechanism of transport inhibition

Abstract (French)

Des travaux anterieurs ont montre, par la technique de saturation en RPE, que la cysteamine presentait la propriete d'inhiber le transport de l'oxygene a travers des membranes phospholipidiques modeles. La meme methodologie, appliquee a des analogues fonctionnels (autres radioprotecteurs) ou structuraux de la cysteamine met en evidence le role specifique des radioprotecteurs aminothiols (cysteamine, WR-1065) dans ce phenomene d'inhibition, dont sont exclus les derives nitriles, l'ethanolamine et les metabolites de la cysteamine
Part of:
Scientific Works 1988. Centre de Recherches du Service de Sante des Armees

Additional details

Additional titles

Original title (French)
Role specifique des radioprotecteurs aminothiols dans l'inhibition du transport transmembranaire de l'oxygene

Publishing Information

Imprint Title
Scientific works 1988. Centre de Recherches du Service de Sante des Armees
Imprint Pagination
263 p.
Journal Page Range
p. 25-26.
Report number
SSA--1989-TS-10

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
21052711
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOCHEMICAL REACTION KINETICS; MEA; MEMBRANES; OXYGEN; PHOSPHOLIPIDS; RADIOPROTECTIVE SUBSTANCES
Descriptors DEC
AMINES; DRUGS; ELEMENTS; ESTERS; KINETICS; LIPIDS; NONMETALS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; ORGANIC SULFUR COMPOUNDS; REACTION KINETICS; RESPONSE MODIFYING FACTORS; THIOLS

Optional Information

Notes
Imprint:Travaux Scientifiques 1988. Centre de Recherches du Service de Sante des Armees.