Published 1975 | Version v1
Book Metadata-only

DNA repair in DNA-polymerase-deficient mutants of Escherichia coli

Creators

  • 1. Univ. of California, San Diego

Description

Escherichia coli mutants deficient in DNA polymerase I, in DNA polymerases I and II, or in DNA polymerase III can efficiently and completely execute excision-repair and postreplication repair of the uv-damaged DNA at 300C and 430C when assayed by alkaline sucrose gradients. Repair by Pol I- and Pol I-, Pol II- cells is inhibited by 1-β-D-arabinofuranosylcytosine (araC) at 430C but not at 300C, whereas that by Pol III- cells is insensitive to araC at any temperature. Thus, either Pol I or Pol III is required for complete and efficient repair, and in their absence Pol II mediates a limited, incomplete dark repair of uv-damaged DNA

Additional details

Publishing Information

Publisher
Plenum Press.
Imprint Place
New York
Imprint Title
Molecular mechanisms for repair of DNA. Part B
Imprint Pagination
p. 473-481.

Conference

Title
DNA repair processes conference.
Dates
Feb 1974.
Place
Squaw Valley, California, USA.

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
7244330
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; DNA; ESCHERICHIA COLI; MUTANTS; POLYMERASES; ULTRAVIOLET RADIATION
Descriptors DEC
BACTERIA; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; ELECTROMAGNETIC RADIATION; ENZYMES; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS

Optional Information

Notes
Imprint:See CONF-740231--PB.