Published June 1988
| Version v1
Journal article
Synthesis of [14C]-labelled dihydropyridine calcium channel entry blockers: nicardipine-[4[14C] and RS-93522-[4-14C]
Description
The Hantzsch synthesis has been applied to the general preparation of 4-aryl-dihydropyridines labelled in the metabolically stable 4-position of the dihydropyridine ring. The synthesis is based on the preparation of a key common intermediate, m-nitrobenzaldehyde-[formyl-14C], in high yield from Ba14CO3. (author)
Additional details
Additional titles
- Augmented title (English)
- Antihypertensive agents
Publishing Information
- Journal Title
- Journal of Labelled Compounds and Radiopharmaceuticals
- Journal Volume
- 25
- Journal Issue
- 6
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 621-626
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 20007644
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ANTIHYPERTENSIVE AGENTS; CARBON 14 COMPOUNDS; CHEMICAL PREPARATION; LABELLING; PYRIDINES; RADIOPHARMACEUTICALS
- Descriptors DEC
- AZINES; CARBON COMPOUNDS; CARDIOVASCULAR AGENTS; DRUGS; HETEROCYCLIC COMPOUNDS; LABELLED COMPOUNDS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOACTIVE MATERIALS; SYNTHESIS