Cell Recovery after Combined Action of Ionizing Radiation and Chemicals

Damage repair in malignant cells would be problematic in sterilization of microorganisms and treatment of cancer, as well. The inhibition of cell recovery and DNA single and double strand breaks repair by chemicals is expressed both as a deceleration of recovery rate and a lesser extent of recovery. Three possibilities are involved in the inhibition of cell recovery: (1) impairment of the recovery process itself, (2) increased irreversible damage, and (3) simultaneous exert of the two. There have been fee publications regarding these problems. The aim of this study was to determine which of these points are involved in the inhibition of cell recovery. In this study, a quantitative approach describing cell recovery from potentially lethal damage as a decrease in the effective dose was used