Published September 1988
| Version v1
Journal article
Identification of a new seventh complementation group of UV-sensitive mutants in Chinese hamster cells
- 1. Rijksuniversiteit Leiden (Netherlands). Lab. voor Stralengenetica en Chemische Mutagenese
- 2. TNO Medical Biological Laboratory, Rijswijk (Netherlands)
Description
The UV-sensitive mutant V-B11, isolated from the V79 Chinese hamster cell line was further characterized. V-B11 has a slightly increased cross-sensitivity to 3me4NQO, whereas no increased sensitivity towards 4NQO was observed. A slighly increased sensitivity towards EMS and MMS was also found. The mutants shows a defect in the ability to perform the incision step of V-B11 was crossed to a panel of 6 UV-sensitive Chinese hamster ovary (CHO) cells, which represents all the previously identified 6 complementation groups of UV-sensitive Chinese hamsters mutants. Since in all crosses complementation has been observed, V-B11 appears to be the first mutant of a new, 7th, complementation group. (author). 18 refs.; 3 figs.; 1 tab
Additional details
Publishing Information
- Journal Title
- Mutation Research, DNA Repair Reports
- Journal Volume
- 194
- Journal Issue
- 2
- Series
- Mutat. Res., DNA Repair Rep.
- Journal Page Range
- 165-170
- ISSN
- 0167-8817
- CODEN
- MUREA
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 20065679
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANIMAL CELLS; BIOASSAY; CHO CELLS; DNA REPAIR; GENETIC RADIATION EFFECTS; HAMSTERS; MUTAGENS; MUTANTS; NEAR ULTRAVIOLET RADIATION; QUINOLINES; SURVIVAL CURVES
- Descriptors DEC
- ANIMALS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; HETEROCYCLIC COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PERFORMANCE TESTING; PYRIDINES; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; TESTING; ULTRAVIOLET RADIATION; VERTEBRATES