Metachronous cancer of both breasts and radiation-induced carcinoma - a case report

A case of female patient presenting bilateral breast cancer, running a metachronous course and radiation-induced laiomyosarcoma is described. A right breast cancer is diagnosed and subjected to complex treatment (pre- and postoperative interstitial radiotherapy, amputation after Patey and chemotherapy course). After a 2-year interval, skin metastases are discovered necessitating ovariectomy, followed by repeated irradiation of the right chest wall with electron beams and polychemotherapy. Twelve years later, leiomyosarcoma involving the operative scar is diagnosed and after 2 years - cancer of the left breast. Proceeding from the results of complex breast cancer treatment, prolongation of the patient's survival in pathologically proved skin metastases is comprehensively discussed. The overall long-term survival is taken to be a precondition of the clinical development of a second primary breast cancer and radiation-induced sarcoma