Published November 1985 | Version v1
Journal article Metadata-only

Indium-111 oxine platelet survival in dogs: effect of doxorubicin and Dacron grafts

Creators

  • 1. William Beaumont Army Medical Center, El Paso, TX

Description

The cytotoxic chemotherapeutic agent doxorubicin was found to acutely decrease platelet survival times in beagle dogs as determined using platelets labeled with [111In]oxine. Recovery was rapid, with platelet survival times returning to normal within 3 wk of cessation of treatment. Doxorubicin also delayed the return of platelet survival times to normal when given to beagle dogs following placement of thoracoabdominal aortic Dacron grafts. It is not known whether or not this may have clinical significance

Additional details

Publishing Information

Journal Title
J. Nucl. Med.
Journal Issue
no.11
Series
J. Nucl. Med.
ISSN
0022-3123
CODEN
JNMEA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
17044114
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BEAGLES; BIOLOGICAL EFFECTS; BLOOD PLATELETS; DIAGNOSIS; DOXORUBICIN; GRAFTS; INDIUM 111; OXINE
Descriptors DEC
ANIMALS; ANTIBIOTICS; ANTINEOPLASTIC DRUGS; AZINES; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; DAYS LIVING RADIOISOTOPES; DOGS; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIDINES; QUINOLINES; RADIOISOTOPES; TRANSPLANTS; VERTEBRATES