Published 1988 | Version v1
Journal article Metadata-only

Quantitative HPLC determination of [99mTc]-pertechnetate in radiopharmaceuticals and biological samples: Pt. 1

Creators

  • 1. Cincinnati Univ., OH (USA). Dept. of Chemistry

Description

Techniques have been developed which allow HPLC (high performance liquid chromatography) to be used for the quantitative determination of [99mTc]pertechnetate in radiopharmaceuticals and biological samples. An instrumental technique accounts for 99mTc species which do not elute from the HPLC column, while a chemical technique obviates interferences caused by Sn(II). These two techniques are incorporated into an anion exchange HPLC procedure which is applied to the determination of [99mTc]pertechnetate in 99mTc-diphosphonate radiopharmaceuticals and biological samples. (author)

Additional details

Additional titles

Subtitle (English)
Technique development

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
15
Journal Issue
5
Series
Nucl. Med. Biol.
Journal Page Range
493-498
ISSN
0883-2897
CODEN
NMBIE

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
20026705
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL MATERIALS; CHROMATOGRAPHY; INTERFERING ELEMENTS; PERTECHNETATES; PHOSPHONATES; QUANTITATIVE CHEMICAL ANALYSIS; RADIOPHARMACEUTICALS; TECHNETIUM 99
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHEMICAL ANALYSIS; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; OXYGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SEPARATION PROCESSES; TECHNETIUM COMPOUNDS; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPOUNDS; YEARS LIVING RADIOISOTOPES

Optional Information

Contract/Grant/Project number
Grant HL-21276; DE-FG02-86ER60487