Published March 2002 | Version v1
Report Metadata-only

High-resolution alpha-autoradiography at subcellular scale using CR-39 plastics with AFM readout

Creators

  • 1. Tokyo Univ., Dept. of Quantum Engineering and Systems Science, Tokyo (Japan)

Description

A new method of high-resolution alpha-autoradiography using CR-39 plastics with AFM readout has been developed for the measurements of boron-compound distribution at subcellular scale in Boron Neutron Capture Therapy. Tumor cells injected by boron compound were mounted on a CR-39 plate, and irradiated by thermal neutrons. Then the plate was exposed to soft X-rays. After etching process in NaOH solution, alpha tracks from B (n, alpha) reactions and a transmission X-ray image of cells were observed simultaneously on the same surface of the CR-39 with an AFM. The resolution of imaging particle tracks and cell structures is several tens of nanometers or less. (author)

Part of:
Proceedings of the workshop. Recognition of DNA damage as onset of successful repair. Computational and experimental approaches

Additional details

Publishing Information

Imprint Title
Proceedings of the workshop. Recognition of DNA damage as onset of successful repair. Computational and experimental approaches
Imprint Pagination
210 p.
Journal Page Range
p. 111-117
Report number
JAERI-Conf--2002-005

Conference

Title
Workshop on recognition of DNA damage as onset of successful repair. Computational and experimental approaches
Dates
18-19 Dec 2001
Place
Tokai, Ibaraki (Japan)

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
37001996
Subject category
S46: INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ALPHA PARTICLES; AUTORADIOGRAPHY; ETCHING; IMAGE PROCESSING; NEUTRON CAPTURE THERAPY; PARTICLE TRACKS; PLASTICS; SOFT X RADIATION; SPATIAL RESOLUTION; SUBCELLULAR DISTRIBUTION
Descriptors DEC
CHARGED PARTICLES; DISTRIBUTION; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MATERIALS; MEDICINE; NEUTRON THERAPY; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC POLYMERS; PETROCHEMICALS; PETROLEUM PRODUCTS; POLYMERS; PROCESSING; RADIATIONS; RADIOLOGY; RADIOTHERAPY; RESOLUTION; SURFACE FINISHING; SYNTHETIC MATERIALS; THERAPY; X RADIATION

Optional Information

Notes
6 refs., 3 figs.; This record replaces 34002099