Published 2003 | Version v1
Miscellaneous Metadata-only

C-11 production with MC-50 cyclotron and synthesis of L-[11C-methyl] methionine

Creators

  • 1. Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of)

Description

L-[11C-methyl] methionine was prepared via no-carrier-added(nca) fast S-alkylation of L-homocysteine with [11C]CH3I using solid support (Al2O3/KF)at room temperature in ethanol. The radiochemical yield of methylation was 90.2%. After reaction, no radiochemical impurity was detected but traces of L-homocysteine precursor were monitored by UV detector. The purification was archived by passing successively through a C18 and alumina sep-pak. the radiochemical purity of L-[11C-methyl] methionine was over 98% after purification and total elapsed time to prepare was 10min from [11C]CH3I delivery

Part of:
Proceedings of the KNS spring meeting

Additional details

Publishing Information

Publisher
KNS
Imprint Place
Taejon (Korea, Republic of)
Imprint Title
Proceedings of the KNS autumn meeting
Imprint Pagination
[CD-ROM]
Journal Page Range
[6 p.]

Conference

Title
2003 spring meeting of the KNS
Dates
29-30 May 2003
Place
Gyeongju (Korea, Republic of)

INIS

Country of Publication
Korea, Republic of
Country of Input or Organization
Korea, Republic of
INIS RN
35064170
Subject category
S07: ISOTOPES AND RADIATION SOURCES; S43: PARTICLE ACCELERATORS;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
AMBIENT TEMPERATURE; CARBON 11; CYCLOTRONS; ISOTOPE PRODUCTION; METHIONINE; PURIFICATION; RADIOCHEMISTRY; SYNTHESIS
Descriptors DEC
ACCELERATORS; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACIDS; CHEMISTRY; CYCLIC ACCELERATORS; DRUGS; EVEN-ODD NUCLEI; ISOTOPES; LIGHT NUCLEI; LIPOTROPIC FACTORS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIOISOTOPES

Optional Information

Notes
5 refs, 4 figs, 2 tabs