Effects of OK-432 on murine bone marrow and the production of natural killer cells
Description
The streptococcal preparation, OK-432, which augments anti-tumor responses in humans and mice, has been shown to be a potent immunomodulator. Among its effects is a pronounced augmentation of natural killer (NK) activity. The hypothesis that OK-432 alters the rates of production and maturation of NK cells in the bone marrow was tested. Studies to determine the kinetic parameters of NK cell production in normal C57BL/6J mice using tritiated thymidine, 3H-TdR, as a DNA marker are described. We are now extending those studies to determine the effect of OK-432 on the bone marrow and on the production of NK cells in the marrow. Initial observations are reported which indicate that OK-432 has profound effects on the cellularity and mitotic activity of the bone marrow, and in particular, on cells with the characteristics of natural killer cells within the marrow. 17 refs., 3 figs., 4 tabs
Availability note (English)
MF available from INIS under the Report Number; Available from NTIS MF A01; 2 as DE87002046.
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Additional details
Publishing Information
- Imprint Pagination
- 7 p.
- Report number
- DOE/EV/10270--T7
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18050869
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- ANTINEOPLASTIC DRUGS; BIOLOGICAL FUNCTIONS; BONE MARROW CELLS; CELL DIFFERENTIATION; ENDOTOXINS; LEUKOCYTES; MICE; TRACER TECHNIQUES; TRITIUM COMPOUNDS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; ANTIGENS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DRUGS; HYDROGEN COMPOUNDS; ISOTOPE APPLICATIONS; MAMMALS; MATERIALS; RODENTS; SOMATIC CELLS; TOXINS; VERTEBRATES
Optional Information
- Notes
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