Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis
Description
Gastric cancer remains the second leading cause of cancer deaths worldwide. Patients usually present late with local invasion or metastatic diseases. The present study investigated the expression level of liver-intestine cadherin (LI-cadherin) by RT-PCR and its correlation with clinicopathological data in 71 pairs of tumor and non-cancerous gastric mucosa. Protein expression level of LI-cadherin was determined by Western blotting and immunohistochemistry. The mRNA of LI-cadherin was highly expressed in tumor as compared to non-cancerous mucosa. Lymph node metastasis was significantly associated with the expression of LI-cadherin (p=0.038). On multivariate analysis, T staging and LI-cadherin expression were found to be independent factors associated with lymph node metastasis
Additional details
Identifiers
- DOI
- 10.1016/j.bbrc.2004.04.197;
- PII
- S0006291X04009969;
Publishing Information
- Journal Title
- Biochemical and Biophysical Research Communications
- Journal Volume
- 319
- Journal Issue
- 2
- Journal Page Range
- p. 562-568
- ISSN
- 0006-291X
- CODEN
- BBRCA9
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 36040270
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- CARCINOMAS; INTESTINES; LIVER; LYMPH NODES; METASTASES; MUCOUS MEMBRANES; POLYMERASE CHAIN REACTION
- Descriptors DEC
- BODY; DIGESTIVE SYSTEM; DISEASES; GASTROINTESTINAL TRACT; GENE AMPLIFICATION; GLANDS; LYMPHATIC SYSTEM; MEMBRANES; NEOPLASMS; ORGANS
Optional Information
- Copyright
- Copyright (c) 2004 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.