Published January 2000 | Version v1
Journal article Metadata-only

Influence of copolymer 2-methyl-5-vinylpyridine with 2-methyl-5-vinylpyridinium-N-oxide on radiation induced myelodepression in mice

Creators

  • 1. GNTs RF, Inst. Biofiziki, Moscow (Russian Federation)

Description

Influence of the new water-soluble copolymer 2-methyl-5-vinylpyridine with 2-methyl-5-vinylpyridinium-N-oxide, which is characterized by expressed curative radioprotective action, on blood formation in mice with experimental cytopenia, induced by the effect of ionizing radiation, is studied. The myelodepression in the animals was caused through the 137Cs gamma-quanta irradiation with the dose of 4 Gy by the dose rate of 1.55 Gy/min. The copolymer was injected once intravascularly with the dose of 400 mg/kg three hours after the radiation impact. It is shown, that the copolymer exerts positive effect on the blood formation state: it decreases the rate of its damage and accelerates the repair process

Abstract (Russian)

Изучено влияние нового водорастворимого сополимера 2-метил-5-винил с 2-метил-5-винилпиридиний-N-оксидом, обладающего выраженным лечебным противолучевым действием, на кроветворение мышей с экспериментальной цитопенией, индуцированной воздействием ионизирующей радиации. Миелодепрессию мышей вызывали облучением животных гамма-квантами 137Сs дозе 4 Гр при мощности 1,55 Гр/мин. Сополимер вводили мышам внутримышечно в дозе 400 мг/кг однократно через 3 часа после лучевого воздействия. Показано, что сополимер оказывает положительное влияние на состояние кроветворения: уменьшает степень его поражения и ускоряет процесс восстановления

Additional details

Additional titles

Original title (Russian)
Влияние сополимера 2-метил-5-винилпиридина с 2-метил-5-винилпиридиний-Н-оксидом на миелодепрессию у мышей, вызванную облучением

Publishing Information

Journal Title
Radiatsionnaya Biologiya, Radioehkologiya
Journal Volume
40
Journal Issue
1
Journal Page Range
p. 58-61
ISSN
0869-8031
CODEN
RBIREJ

INIS

Country of Publication
Russian Federation
Country of Input or Organization
Russian Federation
INIS RN
32054237
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; BLOOD FORMATION; BONE MARROW CELLS; CELL NUCLEI; CESIUM 137; COPOLYMERS; DOSE RATES; GAMMA RADIATION; GAMMA SOURCES; LEUKOCYTES; LYMPHOCYTES; LYMPHOPENIA; MICE; PICOLINES; RADIATION DOSES; RADIOPROTECTIVE SUBSTANCES; TIME DEPENDENCE
Descriptors DEC
ANIMAL CELLS; ANIMALS; AZINES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BLOOD; BLOOD CELLS; BODY FLUIDS; CELL CONSTITUENTS; CESIUM ISOTOPES; CONNECTIVE TISSUE CELLS; DISEASES; DOSES; DRUGS; ELECTROMAGNETIC RADIATION; HEMIC DISEASES; HETEROCYCLIC COMPOUNDS; IMMUNE SYSTEM DISEASES; INTERMEDIATE MASS NUCLEI; IONIZING RADIATIONS; ISOTOPES; LEUKOCYTES; LEUKOPENIA; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC POLYMERS; PATHOLOGICAL CHANGES; POLYMERS; PYRIDINES; RADIATION EFFECTS; RADIATION SOURCES; RADIATIONS; RADIOISOTOPES; REPAIR; RESPONSE MODIFYING FACTORS; RODENTS; SOMATIC CELLS; SYMPTOMS; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
11 refs.