Synthesis and quality analysis of sodium ¹⁸F-fluoroacetate and its precursor

Objective: To synthesize and analyze sodium ¹⁸F-fluoroacetate (FAC) and its precursor ethyl O-mesylglycolate (EOMG). Methods: EOMG was synthesized using modified method. Its chemical purity was checked by HPLC and its structure was elucidated on the basis of spectral analyses. Final product of ¹⁸F-FAC was synthesized based on general nucleophilic reactions module Explora GN using EOMG as a precursor. Liquid chromatography Explora LC was applied to get rid of its chemical impurities. Then HPLC and radio-thin layer chromatography were used to assay its radiochemical purity, chemical purity and specific activity. Results: EOMG was synthesized and identified. Its yield was 70% and its chemical purity was 97.0% (calculated by chromatographic peak area). The radiochemical purity of ¹⁸F-FAC was more than 98%, and its specific activity was 236.5 MBq/μmol. Conclusion: This synthetic method for ¹⁸F-FAC and its precursor can be defined as effective and highly quality-controlled. (authors)