Published September 2015 | Version v1
Journal article Metadata-only

Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

Creators

  • 1. Tumour Microcirculation Group, Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield (United Kingdom)
  • 2. Academic Unit of Radiology, Department of Cardiovascular Science, University of Sheffield (United Kingdom)

Description

Purpose: To estimate the rate constant for pyruvate to lactate conversion in tumours in response to a hypoxic challenge, using hyperpolarised 13C1-pyruvate and magnetic resonance spectroscopy.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radonc.2015.03.011

Additional details

Identifiers

DOI
10.1016/j.radonc.2015.03.011;
PII
S0167814015001486;

Publishing Information

Journal Title
Radiotherapy and Oncology
Journal Volume
116
Journal Issue
3
Journal Page Range
p. 392-399
ISSN
0167-8140
CODEN
RAONDT

INIS

Country of Publication
Ireland
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
50080898
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S60: APPLIED LIFE SCIENCES;
Descriptors DEI
ANOXIA; IN VIVO; MAGNETIC RESONANCE; METABOLISM; NEOPLASMS; RATS
Descriptors DEC
ANIMALS; DISEASES; MAMMALS; RESONANCE; RODENTS; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2017 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.