Published 1986 | Version v1
Journal article Metadata-only

Uptake, distribution and elimination of 3H-gentamicin in different organs of the rat as determined by scintillation counting

Creators

  • 1. Dept. of Biochemistry, Arrhenius Laboratory, University of Stockholm, Stockholm, Sweden

Description

Radioactivity attained in different tissues at different times after a single intraperitoneal injection of 3H-gentamicin into male rats was determined using scintillation counting. After about 30 min. kidney cortex demonstrated 3- to several hundred-fold greater radioactivity than other tissues. Gentamicin was released from kidney medulla and the urinary bladder relatively rapidly, whereas the radioactivity in kidney cortex and thoracal cartilage was maintained for at least 6 hrs. (author)

Additional details

Publishing Information

Journal Title
Acta Pharmacol. Toxicol.
Journal Volume
59
Series
Acta Pharmacol. Toxicol.
Journal Page Range
356-361
ISSN
0001-6683
CODEN
APTOA

INIS

Country of Publication
Denmark
Country of Input or Organization
Denmark
INIS RN
18013305
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANTIBIOTICS; DISTRIBUTION; RATS; SCINTILLATION COUNTING; TRITIUM COMPOUNDS; UPTAKE
Descriptors DEC
ANIMALS; COUNTING TECHNIQUES; DRUGS; HYDROGEN COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; RODENTS; VERTEBRATES