Published October 1989
| Version v1
Journal article
Clinical application of a new antimyosin antibody
- 1. Montreal Univ., PQ (Canada). General Hospital
- 2. Merck Frosst Canada, Inc., Montreal, PQ (Canada)
- 3. Rougier Bio-Tech Ltd., Montreal, PQ (Canada)
Description
A mouse monoclonal antibody, 3-48 (Rougier Bio-Tech Ltd, Montreal) which recognizes the alpha and beta heavy chains of human atrial and ventricular myosin, and the beta heavy chain of human slow skeletal muscle, has recently been developed. In the rat isoproterenol-induced infarction model and the canine model of selective obstruction of a coronary artery, the antibody was shown to be specifically localized to the necrotic myocardium. A selected group of patients with known infarction was imaged with the 111indium labeled F(ab')2 protion of this antibody in a pre-clinical feasibility study, and the results therefrom are reported in this communication. (orig.)
Abstract (German)
Neuerdings ist ein monoklonaler Maus-Antikoerper (3-48, Rougier, Bio-Tech Ltd, Montreal) entwickelt worden, der alpha und beta schwere Ketten menschlichen Vorhof- und Ventrikel-Myokards erkennt, und die beta schwere Kette humaner Skelettmuskulatur. Im Ratten-Modell (Isoproterenol induzierter Infarkt) und im Kaninchen-Modell mit selektiver Obstruktion einer Koronararterie, wurde gezeigt, dass der Antikoerper spezifisch an nekrotischem Myokard lokalisiert ist. Eine selektierte Patientengruppe mit bekanntem Infarkt wurde mit dem 111In-markierten F(ab')2-Fragment dieses Antikoerpers in einer praeklinischen Erprobung untersucht. Die Ergebnisse sind in diesem Kurzbericht zusammengefasst. (orig.)Additional details
Publishing Information
- Journal Title
- Nuc Compact
- Journal Volume
- 20
- Journal Issue
- 5
- Series
- Nuc Compact.
- Journal Page Range
- 150-152
- ISSN
- 0344-3752
- CODEN
- CNNMA
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 21028156
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- DIAGNOSIS; IMAGES; INDIUM 111; LABELLING; MONOCLONAL ANTIBODIES; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOSIN; PATIENTS; RADIOIMMUNODETECTION; RADIOPHARMACEUTICALS; UPTAKE
- Descriptors DEC
- ANTIBODIES; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GLOBULINS; HEART; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; MINUTES LIVING RADIOISOTOPES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; TRACER TECHNIQUES