Published October 1994 | Version v1
Journal article Metadata-only

Synthesis of carbon-14 labeled Taxol (paclitaxel)

Creators

  • 1. Bristol-Myers Squibb Co., Syracuse, NY (United States). Pharmaceutical Research Inst.
  • 2. Bristol-Myers Squibb Co., Wallingford, CT (United States). Pharmaceutical Research Inst.

Description

Reductive cleavage of the C13 side chain of Taxol (1, paclitaxel) followed by regioselective silylation gave 7-triethylsilylbaccatin III (4). 3-O-Triethysilylation of 5 and subsequent reaction with benzoyl chloride-C7-14C gave azetidinone 7. Coupling of 4 and 7 followed by deprotection gave 1.26 g of Taxol-N3'-14C (11) having a specific activity of 26.5 mCi/mmol and a radiochemical purity of 95%. (author)

Additional details

Additional titles

Augmented title (English)
Anticancer agent

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
34
Journal Issue
10
Journal Page Range
p. 973-980.
ISSN
0362-4803
CODEN
JLCRD4

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
26028206
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
ANTINEOPLASTIC DRUGS; CARBON 14 COMPOUNDS; CHEMICAL PREPARATION; LABELLING; RADIOPHARMACEUTICALS; TERPENES
Descriptors DEC
CARBON COMPOUNDS; DRUGS; LABELLED COMPOUNDS; MATERIALS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; SYNTHESIS