Extraosseous tumor uptake of 99m technetium phosphate compounds in children with abdominal neuroblastoma
Description
Sixteen patients with abdominal neuroblastoma had 99m Technetium Phosphate Compounds (99m TC-PC) bone scans as a preoperative evaluation for metastatic disease. Ten patients (62%) had extraosseous tumor uptake while six patients (38%) did not. There was no difference in the incidence of tumor calcification, tumor necrosis or hydronephrosis in the two groups. However, VMA levels were significantly higher in the group with extraosseous tumor uptake. Various bone seeking radionuclides are compared to 99m TC-PC and possible mechanism for extraosseous uptake of such radionuclides are postulated. Awareness of the frequency of such uptake should reduce the possibility of errors in the interpretation of bone scans in patients with neuroblastoma. (orig.)
Abstract (German)
Bei 16 Patienten mit abdominalem Neuroblaston wurden vor der Operation Metastasenuntersuchungen mit Tcsup(99m)Phosphatverbindungen (Tcsup(99m)-Pc) durgefuehrt. Zehn Patienten (62%) hatten eine Aufnahme in den Tumor ausserhalb des Knochens, sechs Patienten (38%) dagegen nicht. In der Haeufigkeit von Tumorverkalkung, Tumornekrose und Hydronephrose bestand kein Unterschied zwischen beiden Gruppen. Der VMAspiegel war in der Gruppe mit Tumoraufnahmen ausserhalb des Knochens signifikant hoeher. Verschiedene knochenspezifische Radionuklide werden mit Tcsup(99m)-PC verglichen und moegliche Mechanismen der Aufnahme derartiger Radionuklide ausserhalb des Knochens postuliert. Das Wissen um die Haeufigkeit dieser Aufnahme kann die Interpretation von Knochenscans bei Patienten mit Neuroblaston erleichtern und Fehler vermeiden helfen. (orig.)Additional details
Publishing Information
- Journal Title
- Pediatr. Radiol.
- Journal Volume
- 7
- Journal Issue
- 3
- Series
- Pediatr. Radiol.
- Journal Page Range
- 159-163
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 10461423
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ABDOMEN; BONE TISSUES; CHILDREN; DIAGNOSIS; ISOMERIC NUCLEI; NEOPLASMS; NERVE CELLS; PATIENTS; SCINTISCANNING; TECHNETIUM 99; WHOLE-BODY COUNTING
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; BODY AREAS; CONNECTIVE TISSUE; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MAN; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; PRIMATES; RADIOISOTOPE SCANNING; RADIOISOTOPES; SOMATIC CELLS; TECHNETIUM ISOTOPES; TISSUES; VERTEBRATES; YEARS LIVING RADIOISOTOPES