Published May 2021 | Version v1
Journal article Metadata-only

High expression of krüppel-like factor 10 or Smad4 predicts clinical benefit of adjuvant chemoradiotherapy in curatively resected pancreatic adenocarcinoma: From a randomized phase III trial

Creators

  • 1. Department of Pathology, National Cheng Kung University, Tainan (China)
  • 2. Department of Surgery, National Cheng Kung University, Tainan (China)
  • 3. Institute of Public Health Sciences, National Health Research Institutes, Miaoli (China)
  • 4. National Institute of Cancer Research, National Health Research Institutes, Miaoli (China)
  • 5. Department of Hematology-Oncology, Linkou Chang-Gung Memorial Hospital, Chang-Gung University, Tao-Yuan (China)
  • 6. Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei (China)
  • 7. Department of Internal Medicine, Mackay Memorial Hospital, Taipei (China)
  • 8. Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University (China)
  • 9. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, and Taipei Cancer Center, Taipei Medical University, Taipei (China)
  • 10. Department of Radiation Oncology, National Cheng Kung University Hospital, National Cheng Kung University, Tainan (China)

Description

Highlights: • The benefit of adjuvant radiotherapy is limited for resected pancreatic adenocarcinoma (PDAC). • The value of Smad 4 in decision of adjuvant chemoradiotherapy (CRT) in PDAC is controversial. • KrÜpple-like factor 10 (Klf10) deficiency correlates with radiation resistance of PDAC. • PDAC patients with high Klf10/Smad4 expression have prolonged survival receiving adjuvant CRT. Our previous studies have demonstrated that Krüppel-like factor 10 (Klf10) modulated tumor radiation resistance and helps to predict clinical outcomes of pancreatic adenocarcinoma (PDAC). This study aimed to evaluate whether the expression levels of Klf10, Smad4 and Runx3 can help predict the benefits of adjuvant chemoradiotherapy (CRT) in resected PDAC.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radonc.2021.02.037

Additional details

Identifiers

DOI
10.1016/j.radonc.2021.02.037;
PII
S0167814021061119;

Publishing Information

Journal Title
Radiotherapy and Oncology
Journal Volume
158
Journal Page Range
p. 146-154
ISSN
0167-8140
CODEN
RAONDT

Conference

Title
World Congress of Brachytherapy. Online Congress
Acronym
WCB 2021
Dates
6-8 May 2021
Place
Brussels (Belgium)

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54013848
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CARCINOMAS; COMBINED THERAPY; PANCREAS; PATIENTS; RADIOTHERAPY
Descriptors DEC
BODY; DIGESTIVE SYSTEM; DISEASES; ENDOCRINE GLANDS; GLANDS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; THERAPY

Optional Information

Copyright
Copyright (c) 2021 Elsevier B.V. All rights reserved.