Preliminary clinical application of 11C-MET PET/CT in the brain glioma patients
- 1. PET Center, Nanfang Hospital, Southern Medical Univ., Guangzhou (China)
Description
Objective: To study the clinical value of 11C-methionine (MET) PET/CT imaging in brain glioma. Methods: 27 cases were studied including 2 glioma, 23 operated glioma and 2 healthy volunteers. 11C-MET PET/CT was performed in all cases but 18F-fluorodeoxyglucose (FDG) PET/CT in only 17 cases. Follow-up period was within 3-17 months. Results: 11C-MET was negative in 4 cases and 18F-FDG negative in 3 cases in group without remnant or recurrent tumor after operation. In 2 cases of initial glioma and 19 cases with remnant or recurrent tumor group, 11C-MET imaging was positive in 20 cases, tumor/gray matter ratio and tumor/white matter ratio were 2.02 ± 0.96, 3.01 ± 1.79, respectively, among them 14 cases also with 18F-FDG imaging showed positive in 12 cases. Lesions showed by 11C-MET were far more clear than that of 18F-FDG. Also tumor/gray matter ratio and the tumor/white matter ratio of 11C-MET imaging were significantly higher than 18F-FDG (2.15 ± 1.16 vs 0.97 ± 0.43, P<0.01; 3.31 ± 2.16 vs 1.90 ± 0.67, P<0.05 ). Conclusion: 11C-MET PET/CT is superior to 18F-FDG PET/CT in the diagnosis and localization of brain glioma. (authors)
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Nuclear Medicine
- Journal Volume
- 25
- Journal Issue
- 5
- Journal Page Range
- p. 286-287
- ISSN
- 0253-9780
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 39031213
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BIOLOGICAL LOCALIZATION; BRAIN; CARBON 11; CAT SCANNING; COMPARATIVE EVALUATIONS; CONTRAST MEDIA; DIAGNOSTIC USES; FLUORINE 18; FLUORODEOXYGLUCOSE; GLIOMAS; IMAGES; METHIONINE; POSITRON COMPUTED TOMOGRAPHY
- Descriptors DEC
- AMINO ACIDS; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVALUATION; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; LIPOTROPIC FACTORS; MINUTES LIVING RADIOISOTOPES; NANOSECONDS LIVING RADIOISOTOPES; NEOPLASMS; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RADIOISOTOPES; TOMOGRAPHY; USES
Optional Information
- Notes
- 4 refs.