Published December 1993 | Version v1
Journal article Metadata-only

Transformation-sensitive cells in G2/M-phase are not promoted by TPA [phorbol 12-myristate 13-acetate] following 137Cs γ-rays

Creators

  • 1. Colorado State Univ., Fort Collins, CO (United States). Dept. of Radiological Health Science

Description

Mouse C3H 10T1/2 cells are most sensitive to radiation-induced neoplastic transformation in the G2/M-phase of the cell cycle. When synchronized 10T1/2 cells were exposed to phorbol 12-myristate 13-acetate (TPA) after α-irradiation, transformation of cells not in the transformation-sensitive window was enhanced, but transformation of cells already in the transformation-sensitive window was not. (Author)

Additional details

Publishing Information

Journal Title
International Journal of Radiation Biology
Journal Volume
64
Journal Issue
6
Journal Page Range
p. 727-730.
ISSN
0955-3002
CODEN
IJRBE7

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
25025227
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CELL CYCLE; GAMMA RADIATION; ONCOGENIC TRANSFORMATIONS; PHORBOL ESTERS; RESPONSE MODIFYING FACTORS; TIME DEPENDENCE
Descriptors DEC
ELECTROMAGNETIC RADIATION; ESTERS; IONIZING RADIATIONS; ORGANIC COMPOUNDS; RADIATIONS