Published May 2024 | Version v1
Journal article Metadata-only

Roles of Junglas nigra husk extract microelements as radioprotectors. An in vivo model using 99mTc-radiopharmaceuticals

Creators

  • 1. The Academy of Applied Preschool Teaching and Health Studies, Krusevac (Serbia)
  • 2. University of Belgrade, Belgrade (Serbia). VINCA Institute of Nuclear Sciences - National Institute of the Republic of Serbia
  • 3. Institute for Oncology and Radiology of Serbia (IORS), Belgrade (Serbia). Department of Radiotherapy Physics
  • 4. University of Belgrade, Belgrade (Serbia). Faculty of Chemistry

Description

The aim of this work was to analyze the multi-elemental composition of the extracts of J. nigra husk, with an assessment of the possible influence of their microelements on biochemical, toxicological and radioprotective effects of in rats exposed to radiation from 99mTc-radiopharmaceuticals. The elements in extract were quantified: microelements (Zn>Al>Se>Cu>Sr>Cr>Ni>Mn>Ba>I>V) and toxic-elements (Pb>Hg>Cd>As). The use of extract in rats showed no clinical evidence of toxicity in terms of biochemical parameters. The results showed significant alteration in the organs accumulation of 99mTc-radiopharmaceuticals. The results showed that extract of J. nigra husk may act as a potential radioprotector of organ system. (author)

Additional details

Publishing Information

Journal Title
Journal of Radioanalytical and Nuclear Chemistry
Journal Volume
333
Journal Issue
5
Journal Page Range
p. 2297-2305
ISSN
0236-5731
CODEN
JRNCDM

INIS

Country of Publication
Hungary
Country of Input or Organization
Hungary
INIS RN
55056900
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
IN VIVO; RADIOPHARMACEUTICALS; RADIOPROTECTIVE SUBSTANCES; RATS; TECHNETIUM 99; TISSUE EXTRACTS
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; RODENTS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
41 refs.