Published May 29, 2013 | Version v1
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Second harmonic scattering characterization of nano-crystals for biomedical imaging

Creators

Description

Non-centrosymmetric nano-crystals show promising nonlinear optical properties for being used as optical labels in bio-imaging applications, with significant interest for observations of long duration and for penetration depth into biological tissues. The development of such biomarkers requires the determination of their nonlinear optical properties to select the best potential markers. In this thesis, Hyper-Rayleigh Scattering (HRS) technique is used to determine nonlinear efficiencies of several nano-crystals (BaTiO3, KNbO3, KTP, LiNbO3, ZnO and BiFeO3). These ensemble measurements have been performed on nano-crystals suspensions, for which the influence of parameters such as size, concentration and aggregation state was discussed. BiFeO3 nano-crystals offer the best nonlinear optical efficiency compared to other particles, showing their potential as efficient optical biomarkers. Polarisation-resolved measurements have also been performed to retrieve individual coefficients of the nonlinear tensor of the investigated materials and influent parameters such as nano-crystals shape have been identified. (author)

Abstract (French)

Les nanocristaux a structure non-centrosymetrique presentent des proprietes optiques non lineaires prometteuses pour une utilisation en tant que marqueurs optiques en imagerie biomedicale, avec un interet significatif en termes de suivi sur de longues durees et de profondeur de penetration dans les tissus biologiques. Le developpement de ces marqueurs necessite la determination de leurs efficacites optiques non lineaires afin de pouvoir selectionner les nanocristaux les plus prometteurs. Pour cela, la technique de diffusion Hyper-Rayleigh a ete adaptee a la caracterisation de suspensions de nanoparticules (BaTiO3, KNbO3, KTP, LiNbO3 et ZnO, BiFeO3) pour lesquelles l'influence de parametres comme la taille, la concentration ou l'etat d'agregation a ete analysee et discutee. Les nanocristaux de BiFeO3 possedent une efficacite optique non lineaire largement superieure aux autres particules, demontrant leur potentiel pour la realisation de nano-sondes optiques particulierement performantes. Des mesures resolues en polarisation ont egalement ete mises en oeuvre pour determiner les coefficients optiques non lineaires independants des particules etudiees. Dans ce cadre, une etude a permis de mettre en evidence l'influence de la forme des nanocristaux sur cette reponse. (auteur)

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Additional details

Additional titles

Original title (French)
Caracterisation par diffusion de second harmonique de nanocristaux pour l'imagerie biomedicale

Publishing Information

Imprint Pagination
163 p.
Report number
FRNC-TH--11147

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
51105387
Subject category
S36: MATERIALS SCIENCE; S75: CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY;
Resource subtype / Literary indicator
Thesis
Descriptors DEI
BIOLOGICAL MARKERS; BISMUTH OXIDES; COLLOIDS; CONTRAST MEDIA; CRYSTAL GROWTH; FERRITES; IODATES; IRON OXIDES; LUMINESCENCE; NANOCRYSTALS; NIOBIUM OXIDES; NONLINEAR OPTICS; OPTICAL PROPERTIES; POLARIZABILITY; POLARIZATION; POTASSIUM OXIDES; RAYLEIGH SCATTERING; SUSPENSIONS
Descriptors DEC
ALKALI METAL COMPOUNDS; BISMUTH COMPOUNDS; CHALCOGENIDES; COHERENT SCATTERING; CRYSTALS; DISPERSIONS; ELECTRICAL PROPERTIES; EMISSION; FERRIMAGNETIC MATERIALS; HALOGEN COMPOUNDS; IODINE COMPOUNDS; IRON COMPOUNDS; MAGNETIC MATERIALS; MATERIALS; NANOSTRUCTURES; NIOBIUM COMPOUNDS; OPTICS; OXIDES; OXYGEN COMPOUNDS; PHOTON EMISSION; PHYSICAL PROPERTIES; POTASSIUM COMPOUNDS; REFRACTORY METAL COMPOUNDS; SCATTERING; TRANSITION ELEMENT COMPOUNDS

Optional Information

Notes
Available from the INIS Liaison Officer for France, see the INIS website for current contact and E-mail addresses